I bought Prince of Persia The Sands of Time earlier this week and just started playing it today. I haven't bothered with POPSOT before because I found the very first fighting bit in The Demo to be too difficult on the keyboard (I died multiple times), but I wanted to play a game that really needed a controlpad.
The 360 controller is easy to setup from the game's option menu and I am thoroughly enjoying it (just brought the city defences online).